Banes
Banes are the universal weaknesses of the Kindred. Damage from banes is multiplied by Blood Potency, making elder vampires paradoxically more vulnerable to the things that can truly hurt them.
Each clan also carries a unique weakness of its own; see Clans.
Sunlight
Sunlight is lethal to the Kindred. Any exposure deals aggravated damage each round, and total exposure — being caught in full daylight with no shelter — will kill a vampire rapidly regardless of HP. Brief exposure through glass, clothing, or shadow still deals damage but at a reduced rate.
Fire
Fire deals aggravated damage and triggers Rötschreck, the terror response of the Beast that compels total flight. Unlike sunlight, fire can be endured with sufficient will, but the Beast must be fought every moment it is present.
Decapitation
Decapitation is one of the few reliable methods of final death, same as prolonged exposure to fire or sunlight.